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LH (Lateral habenula) functionally connects to PVH (Paraventricular hypothalamic nucleus)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Optical activation of LHb axons in the PVN produced TTX-sensitive, 4-AP-restorable EPSCs in oxytocin neurons, consistent with a monosynaptic excitatory connection, and also triggered local oxytocin release detected by the OXT1.7 sensor.
Source: Distinct projections of PVN oxytocin neurons regulate the divergent defensive behaviors in response to social threat
Science Advances, 2026
DOI 10.1126/sciadv.aeb0400 · PubMed 42341137 · PMC13292991, fig. S4, E to L
Named in the paper: “LHb” and “PVN OXT neurons”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Paper reports TTX-sensitive, 4-AP-restored O-EPSCs in PVN OXT neurons from LHb terminals plus OXT1.7 increase, supporting a monosynaptic excitatory functional connection.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.