clm-1bnnjwfn1m

SI (Substantia innominata) functionally connects to Rat basal amygdaloid nucleus principal neurons

Species: Rat
Result: present
Method: optogenetic circuit mapping
Sign: inhibitory
Evidence: Blue-light stimulation of ChR2-expressing NBM terminals in the BLA produced large GABAergic IPSCs in pyramidal neurons; these were blocked by TTX and recovered with 4-AP and had short, exposure-independent latencies, consistent with a direct monosynaptic GABAergic input from the NBM. Chronic intermittent ethanol and withdrawal reduced IPSC amplitude.
Measurements: conduction delay: 2.8 ms (SEM 0.2), n = 12
conduction delay: 2.8 ms (SEM 0.3), n = 8
Source: Chronic Intermittent Ethanol Exposure Dysregulates Nucleus Basalis Magnocellularis Afferents in the Basolateral Amygdala
eneuro, 2022
DOI 10.1523/eneuro.0164-22.2022 · PubMed 36280288 · PMC9668348, Fig. 4B–F
Licence: CC-BY-NC-SA-4.0
Named in the paper: “NBM” and “BLA pyramidal neurons”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-10
“Paper's optogenetic IPSC data, TTX/4-AP test and matching latencies (2.8±0.2, n=12; 2.8±0.3, n=8) support a monosynaptic inhibitory NBM input to BLA pyramidal neurons.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.