clm-1dafftwph9

PVH (Paraventricular hypothalamic nucleus) projects to BST (Bed nuclei of the stria terminalis)

Species: Mouse
Result: present
Method: retrograde tracer
Sign: unknown
Evidence: A retrograde AAV carrying mCherry under an oxytocin promoter injected into the BnST labelled oxytocin-immunoreactive cells throughout the rostral-to-caudal PVN of B6 mice, identifying PVN oxytocin neurons that innervate the BnST; such double-labelled cells were only sparsely found in BTBR mice (strain effect F(1,52) = 18.15, p = 0.0001).
Source: Functional disruption of oxytocin projections participates atypical social and anxiety-like behaviours in BTBR mouse model of autism
Open Biology, 2025
DOI 10.1098/rsob.240387 · PubMed 40858267 · PMC12380489, Fig. 5E,F
Licence: CC-BY-4.0
Named in the paper: “PVN (OXTPVN neurons)” and “BnST”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Retrograde OXT-promoter AAV in BnST labelled OXT-positive PVN neurons in B6, sparse in BTBR, with the stated strain statistic.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.