clm-1f2dj4p4zv
PL (Prelimbic area) functionally connects to BLA (Basolateral amygdalar nucleus)
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- excitatory
- Evidence
- Light activation of ChR2-expressing prelimbic glutamatergic terminals in the BLA reduced centre and open-arm exploration, while NpHR-mediated silencing of the same terminals relieved anxiety-like behaviour in Tmem74-/- mice, without effects on grooming or social novelty.
- Source
Divergent projections of the prelimbic cortex mediate autism- and anxiety-like behaviors
Molecular Psychiatry, 2023
DOI 10.1038/s41380-023-01954-y · PubMed 36690791 · PMC10611563, Supplementary Figs. 6 and 7Licence: CC-BY-4.0
- Named in the paper
- “PL” and “BLA”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-09
“Paper's ChR2 activation and NpHR silencing of PL terminals in BLA support a functional excitatory PL→BLA pathway with the described behavioral specificity.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.