clm-1tgt3qw03y

PL (Prelimbic area) functionally connects to ACB (Nucleus accumbens)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Brief blue light stimulation of ChR2-expressing prelimbic cortical fibers reliably evoked short-latency inward currents and EPSPs in accumbens medium spiny neurons; these responses were completely abolished by the AMPA/kainate blocker DNQX, and the pathway showed strong paired-pulse depression, an AMPA/NMDA ratio near 2.5, and spike-timing dependent LTD but no LTP.
Source: The origin of glutamatergic synaptic inputs controls synaptic plasticity and its modulation by alcohol in mice nucleus accumbens
Frontiers in Synaptic Neuroscience, 2015
DOI 10.3389/fnsyn.2015.00012 · PubMed 26257641 · PMC4507144, Figs. 1B–F, 2A–C, 4, 5, 6
Named in the paper: “prelimbic prefrontal cortex (PFCx)” and “nucleus accumbens (NAc) MSNs”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-10
“Light-evoked, DNQX-sensitive EPSCs and EPSPs from prelimbic inputs onto NAc MSNs, with strong paired-pulse depression, AMPA/NMDA ratio of 2.51 and tLTD only, are all reported.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.