clm-2caf5hpe20

PL (Prelimbic area) functionally connects to BLA glutamatergic principal neurons

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Light activation of ChR2-expressing dorsomedial prefrontal axons in slices produced biphasic currents in basolateral amygdala principal neurons: a short-latency monosynaptic EPSC (about 4 ms onset, abolished by TTX and partly restored with 4-AP) followed by a longer-latency disynaptic IPSC that was blocked by glutamate receptor antagonists or by picrotoxin, indicating feedforward recruitment of local interneurons.
Measurements: conduction delay: 4 ms
Source: Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety
Nature Communications, 2020
DOI 10.1038/s41467-020-15920-7 · PubMed 32376858 · PMC7203160, Fig. 1d–h; Supplementary Fig. 1a–f
Licence: CC-BY-4.0
Named in the paper: “dmPFC” and “BLA PNs”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Optogenetic slice recordings show short-latency (~4 ms) monosynaptic EPSCs in BLA PNs plus disynaptic IPSCs.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.