clm-2w3749b33b

PL (Prelimbic area) functionally connects to BLA (Basolateral amygdalar nucleus)

All claims for this connection

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: unknown
Evidence: ChR2 was expressed in CaMKIIa-positive PL neurons by AAV injection and an LED fiber was placed in the BLA so that PL axon terminals there could be photostimulated. Light delivery in ChR2 mice, but not YFP controls, reduced open-arm time and entries in the elevated plus maze and center time in the open field, and this anxiogenic effect was reversed by the delta-opioid agonist KNT-127, indicating a functional PL-to-BLA pathway. Activation of the same pathway did not change contextual freezing. Note the readout was behavior rather than recorded BLA activity.
Source: The delta opioid receptor agonist KNT‐127 relieves innate anxiety‐like behavior in mice by suppressing transmission from the prelimbic cortex to basolateral amygdala
Neuropsychopharmacology Reports, 2023
DOI 10.1002/npr2.12406 · PubMed 38156409 · PMC10932786, Figures 1B–F and 2A; Results
Licence: CC-BY-4.0
Named in the paper: “prelimbic cortex (PL)” and “basolateral amygdala (BLA)”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“ChR2 in PL CaMKIIa neurons with the optic fiber in BLA produced behavioral effects in ChR2 but not YFP mice, supporting a functional PL-to-BLA pathway in mice as described.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.