clm-54p2ce2d4f

CTX (Cerebral cortex) synapses onto LHA (Lateral hypothalamic area)

Species: Mouse
Result: present
Method: transsynaptic tracer
Sign: unknown
Evidence: Cortical areas contributed a minor share of rabies-labelled monosynaptic inputs to orexin cells.
Source: Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks
Nature Communications, 2016
DOI 10.1038/ncomms11395 · PubMed 27102565 · PMC4844703, Fig. 5; Supplementary Fig. 5
Licence: CC-BY-4.0
Named in the paper: “cortex” and “LH orexin/hypocretin neurons”
Made by: an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-09
“The rank order given for OH inputs puts cortex in the lowest tier, alongside brainstem.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.