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clm-59h2yq841j

ACA (Anterior cingulate area) projects to PAG (Periaqueductal gray)

All claims for this connection
Species
Mouse
Result
present
Method
retrograde tracer
Sign
unknown
Evidence
Injecting retrograde AAV-Cre into the right PAG, combined with Cre-dependent GCaMP8f in the right ACC, labelled ACC neurons that project to the PAG; 312 such neurons were imaged across mice.
Source

Cortical representations of affective pain shape empathic fear in male mice

Nature Communications, 2025

DOI 10.1038/s41467-025-57230-w · PubMed 39994222 · PMC11850870, Fig. 5d, e; Results, PAG-projecting ACC neurons section

Licence: CC-BY-NC-ND-4.0

Named in the paper
“anterior cingulate cortex (ACC)” and “periaqueductal gray (PAG)”
Made by
an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-09
Checked by

a second AI model (claude-opus-5-5) agrees, 2026-10-09

“The paper put retrograde Cre into the PAG and Cre-dependent GCaMP8f into the ACC, and reports 312 PAG-projecting ACC neurons in mice.”

Status

proposed

Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.