clm-78g02vpyvj

Rat central amygdala corticotropin-releasing hormone-expressing neurons functionally connects to CEA (central amygdaloid nucleus)

Species: Rat
Result: present
Method: optogenetic circuit mapping
Sign: modulatory
Evidence: CNO activation of hM3Dq in CeL CRF neurons also induced Fos in a subset of CeM neurons, an effect strongly attenuated by systemic CRF1 receptor blockade with R121919 while activation of the CRF neurons themselves was unaffected.
Source: A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits
Frontiers in Neuroscience, 2015
DOI 10.3389/fnins.2015.00487 · PubMed 26733798 · PMC4689854, Fig. 7D-F
Named in the paper: “CeL CRF neurons” and “CeM”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5) disagrees, 2026-10-10
“The CeM Fos result came from chemogenetic (hM3Dq/CNO) activation, not optogenetic circuit mapping.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.