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DR (Dorsal nucleus raphe) functionally connects to BLA (Basolateral amygdalar nucleus)
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- excitatory
- Evidence
- Single light pulses applied to ChR2-expressing raphe axons produced short-latency EPSCs in just over half of recorded basal amygdala interneurons; these currents were eliminated by combined AMPA/kainate and NMDA receptor blockade, showing glutamate release from 5-HT axons. The responses depressed as stimulation frequency rose from 1 to 20 Hz.
- Measurements
- connection probability: 0.55, n = 59
- Source
Control of Amygdala Circuits by 5-HT Neurons via 5-HT and Glutamate Cotransmission
The Journal of Neuroscience, 2017
DOI 10.1523/jneurosci.2238-16.2016 · PubMed 28087766 · PMC5320609, Fig. 2B,C; Results, 'Activation of 5-HT neurons evokes glutamate-mediated responses in BA INs'Licence: CC-BY-NC-SA-4.0
- Named in the paper
- “DRN (5-HT neurons)” and “BA interneurons (INs)”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-10
“55% of 59 INs showed glutamatergic fast EPSCs abolished by NBQX/APV, depressing at higher frequencies.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.