clm-8v93j8h1aj

PB (Parabrachial nucleus) synapses onto CEA (Central amygdalar nucleus)

All claims for this connection

Species: Mouse
Result: present
Method: electron microscopy
Sign: unknown
Evidence: In the right CeA of 3 mice, CGRP-immunoreactive terminals, which the authors treat as the parabrachial input, formed synapses mainly on dendrites (about 57%), and also on spines (about 24%) and somata (about 19%). Synapses were roughly evenly split between symmetric and asymmetric, and about two thirds of CGRP+ terminals co-expressed vGluT2. The parabrachial origin is inferred from the CGRP marker; it was not traced in this study.
Source: Calcitonin Gene‐Related Peptide (CGRP)‐Containing Terminals in the Central Amygdala of Mice and Monkeys: Ultrastructural Analysis and Subsynaptic Expression of GluD1
European Journal of Neuroscience, 2026
DOI 10.1111/ejn.70607 · PubMed 42460853 · PMC13373983, Figs. 2, 3, 4, 5; Results, Postsynaptic Targets of CGRP+ Terminals
Licence: CC-BY-4.0
Named in the paper: “parabrachial nucleus (CGRP+ PB-CeA terminals)” and “central amygdala (CeA)”
Made by: an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-09
“The mouse EM numbers match the paper (dendrites 56.6%, spines 24.4%, somata 19.0%, symmetric/asymmetric 55/45, vGluT2 66.7%), and the paper itself treats these CGRP+ terminals as the PB-CeA projection, though their PB origin is inferred rather than traced.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.