clm-93cf9dsb11

LHA (Lateral hypothalamic area) functionally connects to VTA (Ventral tegmental area)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: modulatory
Evidence: In VTA dopamine neurons retrogradely labelled from the basolateral amygdala, photostimulation of lateral hypothalamic orexin/dynorphin terminals suppressed evoked firing in two-thirds of cells, an effect blocked by the kappa-opioid antagonist NorBNI; a small, statistically non-significant increase occurred in a quarter of cells, and no change remained when both orexin-1 and kappa-opioid antagonists were present.
Measurements: connection probability: 0.67, n = 12
connection probability: 0.25, n = 12
Source: Distinct Neuromodulatory Effects of Endogenous Orexin and Dynorphin Corelease on Projection-Defined Ventral Tegmental Dopamine Neurons
The Journal of Neuroscience, 2024
DOI 10.1523/jneurosci.0682-24.2024 · PubMed 39187377 · PMC11426376, Fig. 7D–K
Licence: CC-BY-NC-SA-4.0
Named in the paper: “LHox/dyn” and “BLA-projecting VTADA neurons”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-10
“Matches the 8/12 inhibited and 3/12 non-significant increase in BLA-projecting VTA DA neurons with antagonist blockade.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.