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PL (Prelimbic area) functionally connects to BLA (Basolateral amygdalar nucleus)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Blue-light stimulation of ChR2-expressing PrL axon terminals in the BLA evoked short-latency EPSCs in BLA neurons that were abolished by TTX and restored by 4-AP, indicating a monosynaptic excitatory input; conversely, yellow-light activation of NpHR in the same terminals lowered the frequency of spontaneous EPSCs in BLA neurons without altering spontaneous IPSCs.
Source: Elevated prelimbic cortex-to-basolateral amygdala circuit activity mediates comorbid anxiety-like behaviors associated with chronic pain
Journal of Clinical Investigation, 2023
DOI 10.1172/jci166356 · PubMed 36917193 · PMC10145931, Supplemental Fig. 3E–H; Supplemental Fig. 4D–N
Licence: CC-BY-4.0
Named in the paper: “PrL” and “BLA”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“ChR2-evoked short-latency EPSCs with TTX/4-AP test and NpHR-induced sEPSC frequency drop support a monosynaptic excitatory PrL→BLA input.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.