clm-c9a5xy220y

PVH (Paraventricular hypothalamic nucleus) functionally connects to BST (Bed nuclei of the stria terminalis)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: modulatory
Evidence: Chemogenetic excitation of PVN oxytocin neurons lowered AVPR1a mRNA in the BnST of both strains and raised BnST oxytocin receptor mRNA in B6 mice but not in BTBR mice, while c-fos mRNA in the BnST was unchanged, indicating a strain-dependent modulatory action of PVN oxytocin neurons on the BnST.
Source: Functional disruption of oxytocin projections participates atypical social and anxiety-like behaviours in BTBR mouse model of autism
Open Biology, 2025
DOI 10.1098/rsob.240387 · PubMed 40858267 · PMC12380489, Fig. 4; Results, 'mRNA profiles following chemogenetic oxytocin activation'
Licence: CC-BY-4.0
Named in the paper: “OXTPVN neurons” and “BnST”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) disagrees, 2026-10-09
“The manipulation was chemogenetic (hM3Dq/C21), not optogenetic circuit mapping as the evidence type states.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.