clm-d0qe9bte11

PVH (Paraventricular hypothalamic nucleus) functionally connects to ACB (Nucleus accumbens)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: modulatory
Evidence: Light stimulation of ChrimsonR-expressing PVN oxytocin axons in the accumbens produced a rapid rise of the OXT1.7 sensor signal there, indicating oxytocin release from this pathway.
Source: Distinct projections of PVN oxytocin neurons regulate the divergent defensive behaviors in response to social threat
Science Advances, 2026
DOI 10.1126/sciadv.aeb0400 · PubMed 42341137 · PMC13292991, fig. S3, F and G
Named in the paper: “PVN” and “NAc”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Opto-activation of PVN OXT terminals in NAc raised OXT1.7 signal, indicating oxytocin release.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.