clm-h4r4zrchbb

LHA (Lateral hypothalamic area) functionally connects to VTA (Ventral tegmental area)

Species: Mouse
Result: absent
Method: optogenetic circuit mapping
Sign: unknown
Evidence: Attempts to evoke fast AMPA receptor-mediated excitatory postsynaptic currents in VTA neurons by optical stimulation of lateral hypothalamic orexin/dynorphin terminals failed; no light-evoked AMPA currents were detected at -70 mV.
Source: Distinct Neuromodulatory Effects of Endogenous Orexin and Dynorphin Corelease on Projection-Defined Ventral Tegmental Dopamine Neurons
The Journal of Neuroscience, 2024
DOI 10.1523/jneurosci.0682-24.2024 · PubMed 39187377 · PMC11426376, Extended Data Fig. 2-1
Licence: CC-BY-NC-SA-4.0
Named in the paper: “LHox/dyn” and “VTA”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-10
“The paper reports failure to evoke AMPA oEPSCs from LH orexin/dynorphin terminals in VTA.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.