clm-h5e39rsx01

LH (Lateral habenula) functionally connects to DR (Dorsal nucleus raphe)

Species: Rat
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: ChR2 expression in lateral habenula allowed light activation of LHb fibres in DRN, which evoked excitatory currents in mPFC-projecting 5-HT neurons that were blocked by TTX and rescued by 4-AP, showing a direct monosynaptic glutamatergic LHb input. Amplitudes (~47 pA in controls) and paired-pulse ratios were unchanged by prenatal ethanol, and the NO donor SNAP did not modulate these currents.
Source: Chemogenetic inhibition of prefrontal cortex inputs to dorsal raphe reduces anxiety behaviors in male rat model of fetal alcohol spectrum disorder
Scientific Reports, 2025
DOI 10.1038/s41598-025-99181-8 · PubMed 40275074 · PMC12022358, Fig. 2E–H; Fig. 3F–G
Licence: CC-BY-NC-ND-4.0
Named in the paper: “LHb” and “DRNmPFC 5-HT neurons”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Paper shows monosynaptic glutamatergic LHb input to DRNmPFC 5-HT neurons unchanged by PE and NO-insensitive.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.