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PAG (Periaqueductal gray) projects to VTA (Ventral tegmental area)

All claims for this connection
Species
Mouse
Result
present
Method
retrograde tracer
Sign
unknown
Strength
weak
Evidence
About 4 to 6 double-labelled Nts neurons per section were found across roughly 2.5 mm of the PAG, including its lateral and ventrolateral parts. This gives a substantial total number but only a modest density, described as a minor projection.
Source

Determination of neurotensin projections to the ventral tegmental area in mice

Neuropeptides, 2018

DOI 10.1016/j.npep.2018.02.003 · PubMed 29478718 · PMC5906039, Results 3.7; Fig. 11D; Fig. 4; Table 2

Licence: CC-BY-NC-ND-4.0

Named in the paper
“PAG Nts neurons” and “VTA”
Made by
an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-09
Checked by

a second AI model (claude-opus-5-5) agrees, 2026-10-09

“The 4–6 cells per section over about 2.5 mm and the modest density match Results 3.7.”

Status

proposed

Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.