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clm-k4t2qymn42

LHA (Lateral hypothalamic area) projects to VTA (Ventral tegmental area)

All claims for this connection
Species
Mouse
Result
present
Method
anterograde tracer
Sign
unknown
Evidence
Cre-dependent ChR2-mCherry expressed in orexin neurons of the lateral hypothalamus of orexin-cre mice (81% of LH orexin cells labelled, 91% of labelled cells orexin-positive) produced mCherry-labelled axonal fibres visible within the ventral tegmental area alongside tyrosine hydroxylase-positive neurons.
Source

Distinct Neuromodulatory Effects of Endogenous Orexin and Dynorphin Corelease on Projection-Defined Ventral Tegmental Dopamine Neurons

The Journal of Neuroscience, 2024

DOI 10.1523/jneurosci.0682-24.2024 · PubMed 39187377 · PMC11426376, Fig. 1C,E

Licence: CC-BY-NC-SA-4.0

Named in the paper
“LH” and “VTA”
Made by
an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by

a second AI model (claude-opus-5) agrees, 2026-10-10

“ChR2-mCherry in LH orexin neurons labeled fibers in the VTA, consistent with the cited percentages.”

Status

proposed

Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.