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PL (Prelimbic area) synapses onto BLA (Basolateral amygdalar nucleus)
All claims for this connection- Species
- Mouse
- Result
- ambiguous
- Method
- transsynaptic tracer
- Sign
- unknown
- Evidence
- When AAV9 rather than AAV8 was used to deliver CreN-InteinN to the PFC together with retrograde InteinC-CreC in the BLA, Cre-reporter somata appeared in the BLA as well as the PFC; the authors attribute this to anterograde transsynaptic spread of AAV9 to BLA recipient neurons, but the experiment was a specificity control rather than a test of synaptic contact.
- Source
Neural circuit pathology driven by Shank3 mutation disrupts social behaviors
Cell Reports, 2022
DOI 10.1016/j.celrep.2022.110906 · PubMed 35675770 · PMC9210496, Figures S2G-S2I; Results, 'Shank3 mutation in the PFC-BLA neural circuit'Licence: CC-BY-NC-ND-4.0
- Named in the paper
- “PFC” and “BLA”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-09
“The AAV9 control showed Cre-positive BLA somata attributed to transsynaptic spread, which the authors treat only as suggestive.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.