clm-kszczyhy43

LH (Lateral habenula) functionally connects to DR (Dorsal nucleus raphe)

Species: Rat
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Photostimulation of ChR2-expressing lateral habenula fibres in DRN evoked monosynaptic excitatory currents in CeA-projecting 5-HT neurons; amplitudes (about 51 pA in controls) did not differ significantly from prenatal-ethanol rats, but the paired-pulse ratio was strongly reduced after prenatal ethanol, and the NO donor SNAP potentiated these currents only in controls.
Source: Chemogenetic inhibition of prefrontal cortex inputs to dorsal raphe reduces anxiety behaviors in male rat model of fetal alcohol spectrum disorder
Scientific Reports, 2025
DOI 10.1038/s41598-025-99181-8 · PubMed 40275074 · PMC12022358, Fig. 5E–H; Fig. 6F–G
Licence: CC-BY-NC-ND-4.0
Named in the paper: “LHb” and “DRNCeA 5-HT neurons”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“LHb photostimulation evoked monosynaptic oEPSCs in DRNCeA 5-HT neurons with unchanged amplitude, reduced PPR, and SNAP effect only in controls.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.