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LHA (Lateral hypothalamic area) functionally connects to VTA (Ventral tegmental area)

All claims for this connection
Species
Mouse
Result
present
Method
optogenetic circuit mapping
Sign
modulatory
Evidence
In VTA dopamine neurons retrogradely labelled from the medial accumbens shell, photostimulation of lateral hypothalamic orexin/dynorphin terminals raised evoked firing in a minority of cells (orexin-1 receptor dependent) and lowered it in the majority (kappa-opioid receptor dependent); two cells did not respond and the effects were absent with both antagonists applied.
Measurements
  • connection probability: 0.31, n = 13
  • connection probability: 0.54, n = 13
Source

Distinct Neuromodulatory Effects of Endogenous Orexin and Dynorphin Corelease on Projection-Defined Ventral Tegmental Dopamine Neurons

The Journal of Neuroscience, 2024

DOI 10.1523/jneurosci.0682-24.2024 · PubMed 39187377 · PMC11426376, Fig. 6D–K

Licence: CC-BY-NC-SA-4.0

Named in the paper
“LHox/dyn” and “mAcbSh-projecting VTADA neurons”
Made by
an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by

a second AI model (claude-opus-5) agrees, 2026-10-10

“Proportions 4/13 increased and 7/13 decreased with receptor-specific reversal match the text.”

Status

proposed

Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.