clm-m2fn55wgtf

PVH (Paraventricular hypothalamic nucleus) functionally connects to MEA (Medial amygdalar nucleus)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: modulatory
Evidence: Chemogenetic excitation of PVN oxytocin neurons (oxytocin-promoter hM3Dq plus C21) raised oxytocin receptor mRNA in the MeA of both B6 and BTBR mice, although c-fos mRNA in the MeA was not increased by this manipulation, indicating a neuromodulatory influence of the PVN oxytocin population on the MeA.
Source: Functional disruption of oxytocin projections participates atypical social and anxiety-like behaviours in BTBR mouse model of autism
Open Biology, 2025
DOI 10.1098/rsob.240387 · PubMed 40858267 · PMC12380489, Fig. 4; Results, 'mRNA profiles following chemogenetic oxytocin activation'
Licence: CC-BY-4.0
Named in the paper: “OXTPVN neurons” and “MeA”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) disagrees, 2026-10-09
“Evidence type is mislabelled as optogenetic; the paper used DREADD chemogenetic activation with qPCR.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.