clm-nc9ptsv0g6

LA (Lateral amygdalar nucleus) functionally connects to LA glutamatergic principal neurons

Species: Mouse
Result: present
Method: electrical stimulation
Sign: inhibitory
Evidence: Bursts of high-frequency electrical stimuli delivered at the cortical edge of the lateral amygdala, with AMPA, NMDA and GABA-A receptors blocked, produced a slow outward current in lateral amygdala principal neurons that was abolished by the GABA-B antagonist CGP 55845, showing local intra-LA interneuron input mediating slow inhibition; this response was smaller in mice lacking Mecp2 in PV cells.
Source: Loss of the Mecp2 gene in parvalbumin interneurons leads to an inhibitory deficit in the amygdala and affects its functional connectivity
Molecular Autism, 2026
DOI 10.1186/s13229-025-00699-5 · PubMed 41491494 · PMC12829049, Fig. 5a
Licence: CC-BY-4.0
Named in the paper: “lateral amygdala (LA)” and “principal neurons (PNs) in the lateral amygdala”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-09
“In Fig. 5a, local electrical stimulation within the LA under glutamate and GABA-A block evokes a CGP 55845-sensitive slow GABA-B current in LA principal neurons, and this current is reduced in knockouts.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.