clm-pjfycwg52p

CA1 (Field CA1) functionally connects to BLA glutamatergic principal neurons

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: In slices, light activation of ChR2-expressing ventral CA1 axons evoked a monosynaptic EPSP in BA principal neurons, followed by disynaptic IPSPs that were abolished by glutamate receptor antagonists. In vivo, theta burst photostimulation suppressed principal neuron firing.
Measurements: connection probability: 0.66, n = 122
connection probability: 0.15, n = 122
Source: Hippocampal Theta Input to the Amygdala Shapes Feedforward Inhibition to Gate Heterosynaptic Plasticity
Neuron, 2015
DOI 10.1016/j.neuron.2015.08.024 · PubMed 26402610 · PMC4590554, Figs. 2D-E, 3A-C, 3H-J, S4
Licence: CC-BY-4.0
Named in the paper: “vCA1 pyramidal cell axons” and “BA principal neurons (PNs)”
Made by: an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Percentages 66% (80/122) and 15% (18/122) of PNs showing light-evoked EPSP-IPSP sequences match the paper as fractions.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.