clm-r0hnpq1dvn

ACB (Nucleus accumbens) synapses onto VTA (Ventral tegmental area)

Species: Mouse
Result: present
Method: transsynaptic tracer
Sign: unknown
Evidence: Rabies tracing from VTA dopamine neurons labelled input cells in the medial shell, lateral shell and core of the nucleus accumbens; accumbens labelling (medial shell and core) was reduced after a single dose of an addictive drug, and CRISPRi knockdown of Cacna1e in the lateral shell lowered the number of rabies-labelled accumbens inputs to VTA dopamine cells.
Source: Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing
eLife, 2026
DOI 10.7554/elife.93664 · PubMed 42138352 · PMC13179063, Fig. 1C, Fig. 5D–E, Fig. 10F
Licence: CC-BY-4.0
Named in the paper: “NAcMed, NAcLat, NAcCore” and “VTADA cells (DAT-Cre VTA dopamine neurons)”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-10
“All three accumbens subregions are quantified inputs, NAcMed/NAcCore reduced by drugs, and Cacna1e knockdown lowered NAcLat labeling.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.