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BLA (Basolateral amygdalar nucleus) functionally connects to ACB (Nucleus accumbens)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Light activation of ChR2-expressing fibers from the basal amygdala evoked glutamatergic AMPA- and NMDA-mediated EPSCs/EPSPs in accumbens medium spiny neurons; pairing with postsynaptic spikes produced LTP in 8 of 14 recorded MSNs and LTD in the remaining 6, and the AMPA/NMDA ratio averaged 2.51.
Measurements: connection probability: 0.571, n = 14
Source: The origin of glutamatergic synaptic inputs controls synaptic plasticity and its modulation by alcohol in mice nucleus accumbens
Frontiers in Synaptic Neuroscience, 2015
DOI 10.3389/fnsyn.2015.00012 · PubMed 26257641 · PMC4507144, Figs. 2D–G, 3, 4, 5, 6, 8A–B
Named in the paper: “amygdala basal nucleus” and “nucleus accumbens (NAc) MSNs”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5-5) disagrees, 2026-10-10
“The 8/14 (0.571) figure is the fraction of MSNs showing tLTP, not a connection probability, so the number is misattributed.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.