clm-tc7ktz17kt
BLA (Basolateral amygdalar nucleus) functionally connects to ACB (Nucleus accumbens)
All claims for this connection- Species
- Mouse
- Result
- present
- Method
- optogenetic circuit mapping
- Sign
- excitatory
- Evidence
- Light activation of ChR2- or Chronos-expressing BLA axons in accumbens slices evoked AMPAR- and NMDAR-mediated excitatory postsynaptic currents in identified D1 medium spiny neurons; the AMPA/NMDA ratio of this input was reduced in depressive-like morphine-withdrawn mice, and the input could be potentiated by paired optogenetic high-frequency stimulation.
- Source
Nucleus accumbens D1/D2 circuits control opioid withdrawal symptoms in mice
Journal of Clinical Investigation, 2023
DOI 10.1172/jci163266 · PubMed 37561576 · PMC10503809, Fig. 4A, C; Fig. 7A-CLicence: CC-BY-4.0
- Named in the paper
- “BLA” and “NAc D1 MSNs”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-09
“BLA-input oEPSCs in identified D1 MSNs showed reduced A/N in Mor-D mice and oHFS+oPSD-induced LTP.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.