clm-tpk57vmbt7
CA1 (Field CA1) functionally connects to PL (Prelimbic area)
All claims for this connection- Species
- Mouse
- Result
- ambiguous
- Method
- optogenetic circuit mapping
- Sign
- unknown
- Evidence
- Light activation of ChR2-expressing GRP terminals from ventral CA1 in the mPFC did not change scratching relative to controls; since only behaviour, not mPFC neuronal activity, was measured, the functional efficacy of this anatomically present pathway remains unresolved.
- Source
A prefrontal peptidergic circuit for psychogenic itch
Science Advances, 2026
DOI 10.1126/sciadv.aed8901 · PubMed 42585325 · PMC13464479, Fig. 3H- Named in the paper
- “GRP neurons in vCA1 (vCA1→mPFC terminals)” and “mPFC”
- Made by
- an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
- Checked by
a second AI model (claude-opus-5) agrees, 2026-10-09
“Fig. 3H reports no significant behavioral effect of vCA1 terminal stimulation, so functional efficacy is unresolved though the anatomical input exists.”
- Status
proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.