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BMA (Basomedial amygdalar nucleus) functionally connects to IA (Intercalated amygdalar nucleus)

All claims for this connection

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Unilateral in vivo blue-light stimulation of ChR2-expressing PACAP BMA neurons that project to the mICCs raised the number of cfos-positive cells in the ipsilateral mICCs relative to the unstimulated hemisphere. In slices, single light flashes over ChR2-expressing BMA PACAPergic fibres evoked EPSCs in most recorded mICC neurons; these were abolished by TTX, restored/increased by TTX plus 4-AP (consistent with a monosynaptic connection), and blocked by CNQX, showing glutamate release from BMA terminals. The PAC1 antagonist PACAP 6-38 increased EPSC amplitude without changing the paired-pulse ratio.
Measurements: connection probability: 0.438, n = 32
connection probability: 0.25, n = 32
Source: A Basomedial Amygdala to Intercalated Cells Microcircuit Expressing PACAP and Its Receptor PAC1 Regulates Contextual Fear
The Journal of Neuroscience, 2021
DOI 10.1523/jneurosci.2564-20.2021 · PubMed 33637560 · PMC8051692, Figs. 3A–D, 4C–I
Licence: CC-BY-NC-SA-4.0
Named in the paper: “BMA” and “mICCs”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-10
“In vivo cfos increase and light-evoked, CNQX-sensitive, TTX/4-AP-tested EPSCs in mICC neurons support an excitatory functional connection with the stated response proportions out of 32 cells.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.