clm-y73zz6rkq7

Rat central amygdala corticotropin-releasing hormone-expressing neurons functionally connects to CEA (central amygdaloid nucleus)

Species: Rat
Result: present
Method: optogenetic circuit mapping
Sign: modulatory
Evidence: Chemogenetic activation of CeL CRF neurons with hM3Dq plus CNO induced Fos in non-CRF CeL neurons (absent with hM4Di or mCherry controls), and this Fos induction was reduced by about two-thirds by the CRF1 receptor antagonist R121919, indicating peptidergic excitation via local CRF release.
Source: A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits
Frontiers in Neuroscience, 2015
DOI 10.3389/fnins.2015.00487 · PubMed 26733798 · PMC4689854, Fig. 7A-F
Named in the paper: “CeL CRF neurons” and “non-CRF neurons of the CeL”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5) disagrees, 2026-10-10
“The CRF1-dependent Fos induction in CeL non-CRF neurons was obtained chemogenetically, not by optogenetic circuit mapping.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.