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BLA (Basolateral amygdalar nucleus) projects to ACA (Anterior cingulate area)

Species: Mouse
Result: present
Method: retrograde tracer
Sign: unknown
Evidence: A retrograde CaMKIIα virus placed in the ACC labelled cell bodies in the BLA, most of which were also immunopositive for glutamate; these ACC-projecting BLA cells made up most of the activity-labelled (c-fos positive) BLA population in the pain/anxiety model. The same retrograde strategy was used to target these neurons for recording and calcium imaging.
Source: The basolateral amygdala-anterior cingulate cortex circuit contributes to postherpetic neuralgia-anxiety comorbidity
Theranostics, 2025
DOI 10.7150/thno.111130 · PubMed 40225572 · PMC11984391, Fig. 6B-F; Fig. 9A-B
Named in the paper: “BLA” and “ACC”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-10
“The retrograde CaMKIIα virus in ACC labeled BLA neurons that were mostly glutamate-positive and made up about 70% of c-fos+ BLA cells, and it was reused to target these cells for recording.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.