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LHA (Lateral hypothalamic area) functionally connects to VTA (Ventral tegmental area)

All claims for this connection
Species
Mouse
Result
present
Method
optogenetic circuit mapping
Sign
modulatory
Evidence
In VTA dopamine neurons retrogradely labelled from the lateral accumbens shell, optical stimulation of lateral hypothalamic orexin/dynorphin terminals increased evoked firing in most cells (reversed by the orexin-1 receptor antagonist) and decreased it in a smaller group (reversed by the kappa-opioid antagonist); one cell was unchanged and no effect remained when both antagonists were present.
Measurements
  • connection probability: 0.55, n = 11
  • connection probability: 0.36, n = 11
Source

Distinct Neuromodulatory Effects of Endogenous Orexin and Dynorphin Corelease on Projection-Defined Ventral Tegmental Dopamine Neurons

The Journal of Neuroscience, 2024

DOI 10.1523/jneurosci.0682-24.2024 · PubMed 39187377 · PMC11426376, Fig. 5D–K

Licence: CC-BY-NC-SA-4.0

Named in the paper
“LHox/dyn” and “lAcbSh-projecting VTADA neurons”
Made by
an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by

a second AI model (claude-opus-5) agrees, 2026-10-10

“6/11 increased and 4/11 decreased in lAcbSh-projecting neurons, as reported.”

Status

proposed

Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.