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BLA (Basolateral amygdalar nucleus) functionally connects to ACB (Nucleus accumbens)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: modulatory
Evidence: Optogenetic silencing (eNpHR3, green light) of BLA NPY axon terminals in the accumbens reduced the number of c-Fos-positive accumbens neurons compared with GFP controls, while blue-light activation of ChR2-expressing BLA NPY terminals tended to raise accumbens c-Fos on the stimulated side; accompanying pharmacology showed accumbens Y1 receptors mediate the behavioural effect.
Source: Neuropeptide Y neurons in the basolateral amygdala project to the nucleus accumbens and stimulate high-fat intake
Frontiers in Cellular Neuroscience, 2025
DOI 10.3389/fncel.2025.1565939 · PubMed 40213497 · PMC11983651, Supplementary Fig. 3; Results 3.3, 3.4
Licence: CC-BY-4.0
Named in the paper: “BLA” and “NAc”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-10
“Terminal optogenetic manipulation in NAc changed NAc c-Fos (significant decrease with eNpHR3, trend increase with ChR2), supporting a modulatory functional link.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.