Mouse

VTA (Ventral tegmental area) functionally connects to ACB (Nucleus accumbens)

1 claim from 1 source: 1 found, 0 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-9kc5qdvwrspresentoptogenetic circuit mappingproposed

When ChrimsonR was expressed non-specifically (CamKIIa promoter in wild-type mice, labelling both dopaminergic and GABAergic VTA cells), photo-stimulation of the VTA did not change accumbal dopamine (p = 0.0677 at 2 Hz, p = 0.416 at 20 Hz). After systemic bicuculline, the same non-specific VTA stimulation significantly increased dopamine in the NAcShell (p = 0.00452 at 2 Hz, p = 0.000243 at 20 Hz), so a functional VTA-to-NAcShell dopaminergic link exists but is masked by local GABAergic inhibition. Light delivery alone in control mice without ChrimsonR produced no change (p = 0.0923 and 0.129).

DOI 10.3390/ijms23031114 · PubMed 35163036 · PMC8834722, Fig. 3(c-1,c-2) and Fig. 3(d-1,d-2); Results 2.3

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