Mouse
PL (Prelimbic area) projects to CP (Caudoputamen)
5 claims from 4 sources: 4 found, 0 tested and absent, 1 ambiguous. Evidence: anterograde tracer, retrograde tracer. Strongest reported: strong.
The claims behind it
After injecting a CaMKIIα-driven EGFP AAV into the prelimbic cortex, labelled axons were abundant in the dorsal striatum.
DOI 10.1038/s41380-023-01954-y · PubMed 36690791 · PMC10611563, Fig. 4aMade by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.
A third CTB color injected into dorsomedial striatum labelled PL upper-layer pyramidal cells at a characteristic depth.
DOI 10.1038/nn.4624 · PubMed 28825718 · PMC5614838, Fig. 1c-dMade by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.
Retrograde AAV2-Retro-DIO-EGFP injected in the dorsal striatum of CaMKIIα-Cre mice labelled pyramidal neurons in the prelimbic cortex; these cells lay more laterally than BLA-projecting cells and overlapped only minimally with them.
DOI 10.1038/s41380-023-01954-y · PubMed 36690791 · PMC10611563, Fig. 5a–fMade by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.
Labelled axons of PFC neurons were visible within the medial striatum, but the authors describe these as fibres coursing through the striatum on their way to terminate in the BLA, so striatal innervation is not established.
DOI 10.1016/j.celrep.2022.110906 · PubMed 35675770 · PMC9210496, Figures 1E and 1FMade by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.
Axons of ChR2-eYFP labelled prefrontal D1 neurons were prominent in the dorsomedial striatum.
DOI 10.1038/nn.3625 · PubMed 24441680 · PMC3968853, Supplemental Fig. 7a,b; Results, 'Downstream targets of mPFC stimulation'Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.