Rat

CEA (central amygdaloid nucleus) functionally connects to ACB (Nucleus accumbens)

2 claims from 2 sources: 1 found, 0 tested and absent, 1 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-jygx61xv47presentoptogenetic circuit mappingproposed

CeA ChR2 stimulation paired with sucrose/cocaine pursuit or with shock-rod attraction was followed by elevated Fos in the rostromedial quadrant of nucleus accumbens medial shell (over 700% above baseline in the reward group; over 180% above eYFP in the shock-rod group), whereas caudal medial shell showed no significant change.

DOI 10.1038/s41467-020-16407-1 · PubMed 32483118 · PMC7264246, Results, 'Shock-rod attraction activates mesocorticolimbic circuity'; Fig. 5; Supplementary Table 1

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

clm-qt3vte05ekambiguousoptogenetic circuit mappingproposed

Because viral injection could spill into the adjacent central amygdala, the authors tested whether GABAergic input contributed to the light-evoked accumbens responses; picrotoxin reduced the responses only marginally (about 7% in 22 cells from 4 rats), which they took as evidence against a functional contribution of central amygdala fibres, though the connection itself was not directly assayed.

DOI 10.1038/nn.3533 · PubMed 24077564 · PMC3815713, Results, 'Recording of BLA-to-NAc shell excitatory synapses'

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) is unsure. “The picrotoxin test only shows negligible GABAergic contribution and the no-CeA-projection statement is cited from prior work, so whether 'ambiguous' is the paper's own result is unclear.”