Rat
BLN (basolateral amygdaloid nuclear complex) projects to PL (Prelimbic area)
3 claims from 2 sources: 3 found, 0 tested and absent, 0 ambiguous. Evidence: anterograde tracer, retrograde tracer.
The claims behind it
AAV-CaMKIIa-ChR2-eYFP or ArchT-GFP expressed in BLA labelled axon terminals in the medial prefrontal cortex. These terminals were targeted by optical fibers placed in dorsal PL.
DOI 10.1038/nn.4553 · PubMed 28436980 · PMC5448704, Fig. 6a; Fig. 7a; Supplementary Fig. S8aMade by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) is unsure. “The paper expressed opsins in BLA to manipulate terminals in mPFC, but the available text never shows labelled terminals, and that histology is only in a supplementary figure that is not described.”
Retrograde CAV2-Cre injected into PL, combined with Cre-dependent ChR2 or hM4D(Gi) in BLA, labelled PL-projecting BLA neurons. These were confirmed in slices and photoidentified in vivo, where 11 of 60 recorded BLA units (18%) responded at short latency.
DOI 10.1038/nn.4553 · PubMed 28436980 · PMC5448704, Fig. 4a-c, 4f-h; Fig. 7gMade by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.
After AAV9-CaMKIIa-hM4Di-mCherry injection into the BLA, mCherry-labelled axonal boutons were detected and counted in layers 2 and 5 of the prelimbic cortex, with layer 2 receiving more boutons than layer 5; maternal separation increased bouton counts.
DOI 10.1016/j.ynstr.2025.100753 · PubMed 41050508 · PMC12489772, Fig. 3A-F; Results, section 'Chemogenetic BLA inhibition'Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.