Temporal Association Cortex Gates Sound‐Evoked Arousal from NREM Sleep

TEa (Temporal association areas) MBA:541 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Retrograde AAV-Cre injection into the BLA/La region labelled projection neurons in TeA layers 2–5, mostly glutamatergic.

Fig. 5D–G

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TEa (Temporal association areas) MBA:541 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

RetroAAV-Cre injected into BLA/La of Ai14 mice retrogradely labelled TeA neurons (including part of ectorhinal cortex), located in layers 2–5 and about 82% glutamatergic; 178 cells counted from 4 mice.

Fig. 5D–G

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TEa (Temporal association areas) MBA:541 synapses onto LC (Locus ceruleus) MBA:147 · Mouse

Anterograde transsynaptic AAV1-Cre tracing from TeA labelled downstream neurons in the locus coeruleus.

Fig. 4B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TEa (Temporal association areas) MBA:541 projects to LP (Lateral posterior nucleus of the thalamus) MBA:218 · Mouse

Anterograde non-transsynaptic tracing from TeA labelled axons in the mediorostral lateral posterior thalamic nucleus.

Fig. 4A

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TEa (Temporal association areas) MBA:541 functionally connects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Optogenetic activation of TeA CaMKIIα+ axon terminals in slices produced depolarizing EPSPs that drove spikes and inward EPSCs in VGluT2+ neurons of the BLA/La region.

Fig. 5H–K

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TEa (Temporal association areas) MBA:541 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Anterograde non-transsynaptic tracing from TeA labelled axons in the lateral amygdala.

Fig. 4A

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TEa (Temporal association areas) MBA:541 functionally connects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

In acute slices from VGluT2-Cre mice, photostimulating ChR2-expressing TeA CaMKIIα+ terminals evoked EPSPs, action potentials and large EPSCs in mCherry-labelled glutamatergic BLA/La neurons.

Fig. 5H–K

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TEa (Temporal association areas) MBA:541 synapses onto BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

AAV1-Cre in TeA of Ai14 mice labelled postsynaptic neurons in the basolateral amygdala; about 91% of these TeA-recipient BLA/La cells were glutamate-immunopositive and about 8% GABAergic.

Fig. 4B; Fig. 5A–C

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TEa (Temporal association areas) MBA:541 synapses onto LP (Lateral posterior nucleus of the thalamus) MBA:218 · Mouse

Anterograde transsynaptic AAV1-Cre tracing from TeA labelled neurons in the mediorostral lateral posterior thalamus, which were then targeted for calcium recording.

Fig. 4B; Fig. 4K–M

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TEa (Temporal association areas) MBA:541 projects to RE (Nucleus of reuniens) MBA:181 · Mouse

Anterograde non-transsynaptic tracing from TeA labelled axons in the ventral reuniens thalamic nucleus.

Fig. 4A

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TEa (Temporal association areas) MBA:541 synapses onto RE (Nucleus of reuniens) MBA:181 · Mouse

Anterograde transsynaptic AAV1-Cre tracing from TeA labelled downstream neurons in the ventral reuniens nucleus.

Fig. 4B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TEa (Temporal association areas) MBA:541 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Anterograde non-transsynaptic tracing from TeA labelled axons in the basolateral amygdala.

Fig. 4A

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TEa (Temporal association areas) MBA:541 synapses onto CLA (Claustrum) MBA:583 · Mouse

Anterograde transsynaptic AAV1-Cre tracing from TeA labelled downstream neurons in the claustrum.

Fig. 4B

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TEa (Temporal association areas) MBA:541 projects to sAMY (Striatum-like amygdalar nuclei) MBA:278 · Mouse

Non-transsynaptic anterograde viral tracing from TeA showed eYFP-labelled fibres in the amygdalostriatal transition area, one of the most prominent targets.

Fig. 4A

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TEa (Temporal association areas) MBA:541 synapses onto sAMY (Striatum-like amygdalar nuclei) MBA:278 · Mouse

AAV1-Cre injected into TeA of Ai14 mice produced tdTomato-labelled postsynaptic somata in the amygdalostriatal transition area.

Fig. 4B

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TEa (Temporal association areas) MBA:541 projects to LC (Locus ceruleus) MBA:147 · Mouse

Anterograde non-transsynaptic tracing from TeA labelled axons in the locus coeruleus, listed among the prominent downstream targets.

Fig. 4A

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TEa (Temporal association areas) MBA:541 projects to CLA (Claustrum) MBA:583 · Mouse

Anterograde non-transsynaptic tracing from TeA labelled axons in the claustrum.

Fig. 4A

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

TEa (Temporal association areas) MBA:541 synapses onto LA (Lateral amygdalar nucleus) MBA:131 · Mouse

AAV1-Cre anterograde transsynaptic labelling from TeA marked postsynaptic neurons in the lateral amygdala, mostly glutamatergic by immunostaining.

Fig. 4B; Fig. 5A–C

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