Topographic Mesocortex-Amygdalar Projections Expand the Molecular and Functional Model of the Limbic System

VISl (Lateral visual area) MBA:409 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

A lateral visual area injection (VISl-0.252) labelled the intermediate stratum of the lateral domain.

Fig. 5n–p

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PERI (Perirhinal area) MBA:922 projects to CEA (Central amygdalar nucleus) MBA:536 · Mouse

Perirhinal injections produced abundant labelling in the subpallial central amygdala.

Fig. 3h–k

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PERI (Perirhinal area) MBA:922 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Perirhinal projections reached the most rostral intermediate stratum of the lateral domain.

Fig. 3h, i

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AUD (Auditory areas) MBA:247 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

The basolateral subdomain received few auditory cortex projections, possibly from spread into adjacent mesocortex.

Fig. 5l, m

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AI (Agranular insular area) MBA:95 projects to BMA (Basomedial amygdalar nucleus) MBA:319 · Mouse

Insular injections did not label the basomedial subdomain.

Fig. 4b–h

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ORBm (Orbital area, medial part) MBA:731 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Allen anterograde injections into medial posterior orbital mesocortex (6 cases) labelled terminals mainly in the medial basolateral subdomain, covering its inner and outer intermediate, superficial and periventricular strata.

Fig. 2a–e; Table 1

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PERI (Perirhinal area) MBA:922 projects to MEA (Medial amygdalar nucleus) MBA:403 · Mouse

Abundant perirhinal terminal labelling was seen in rostral posterodorsal medial amygdala.

Fig. 3h–k

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AI (Agranular insular area) MBA:95 projects to CEA (Central amygdalar nucleus) MBA:536 · Mouse

The central amygdala clearly received labelled insular projections.

Fig. 4b–d, g

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ECT (Ectorhinal area) MBA:895 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Ectorhinal injections also labelled the inner intermediate stratum of the medial basolateral subdomain.

Fig. 3l–n

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MOs (Secondary motor area) MBA:993 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Secondary motor/frontal association injections labelled terminals from the rostral intermediate lateral basolateral subdomain and its superficial stratum.

Fig. 5a–j

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

VISpor (Postrhinal area) MBA:312782628 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Postrhinal injections labelled the intermediate and periventricular strata of the lateral domain, possibly due to spread into visual cortex.

Fig. 3d–f

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

VISpor (Postrhinal area) MBA:312782628 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Postrhinal injections also labelled the inner intermediate stratum of the medial basolateral subdomain.

Fig. 3d–f

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ACA (Anterior cingulate area) MBA:31 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Rostral cingulate injections labelled mainly the periventricular and inner intermediate strata of the medial basolateral subdomain, without clear superficial labelling.

Fig. 2k–m; Table 1

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AUD (Auditory areas) MBA:247 projects to BMA (Basomedial amygdalar nucleus) MBA:319 · Mouse

Some collateral auditory cortex labelling ran along the basomedial subdomain.

Fig. 5m

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MOs (Secondary motor area) MBA:993 projects to CEA (Central amygdalar nucleus) MBA:536 · Mouse

Frontal association cortex injections labelled the subpallial central amygdala.

Fig. 5b–f

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ECT (Ectorhinal area) MBA:895 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Ectorhinal injections (representative VISpor-0.367) labelled the intermediate stratum of the lateral domain, possibly with spread into visual cortex.

Fig. 3l–n

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PERI (Perirhinal area) MBA:922 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Perirhinal injections (representative VISC-0.450) labelled all strata of the lateral basolateral subdomain, with some additional labelling in medial basolateral strata.

Fig. 3g–k; Fig. 6b,d

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ORB (Orbital area) MBA:714 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Ventrolateral posterior orbital injections (representative ORBl-0.317) labelled the intermediate stratum of the lateral basolateral subdomain, with no significant input elsewhere in pallial amygdala.

Fig. 4l–n; Table 1

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AI (Agranular insular area) MBA:95 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Agranular and dysgranular insular injections labelled the intermediate and superficial strata of the lateral basolateral subdomain and the inner medial basolateral subdomain.

Fig. 4a–k

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AI (Agranular insular area) MBA:95 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

In the illustrated insular cases no labelling was seen in the lateral radial domain.

Fig. 4b–h

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ORBm (Orbital area, medial part) MBA:731 projects to BMA (Basomedial amygdalar nucleus) MBA:319 · Mouse

The basomedial subdomain received practically no projections from POrbM injections.

Fig. 2a–e

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PL (Prelimbic area) MBA:972 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Prelimbic injections (9 cases, representative PL-0.391) labelled predominantly the strata of the medial basolateral subdomain, confirmed in virtual sagittal and horizontal planes.

Fig. 2f–j; Fig. 6a,c; Table 1

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ORBm (Orbital area, medial part) MBA:731 projects to MEA (Medial amygdalar nucleus) MBA:403 · Mouse

The subpallial posterodorsal medial amygdala showed anterograde labelling after POrbM injections.

Fig. 2b–d

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MOs (Secondary motor area) MBA:993 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Labelling from MOs injections extended into the intermediate stratum of the lateral domain adjacent to the amygdalar capsule.

Fig. 5d–f, j

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AUD (Auditory areas) MBA:247 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Auditory cortex injections (representative AUDp-0.423) produced labelling centered on the intermediate and periventricular strata of the lateral domain.

Fig. 5k–m

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

RSPagl (Retrosplenial area, lateral agranular part) MBA:894 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Parasplenial injections gave comparatively scarce, weak terminal labelling, mainly in the inner intermediate stratum of the medial basolateral subdomain.

Fig. 3a–c; Table 1

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ORBm (Orbital area, medial part) MBA:731 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

POrbM injections produced practically no labelling in any stratum of the lateral radial amygdalar domain.

Fig. 2a–e

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

VISl (Lateral visual area) MBA:409 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

The same visual cortex injection also labelled the inner intermediate stratum of the medial basolateral unit.

Fig. 5o, p

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PERI (Perirhinal area) MBA:922 projects to BMA (Basomedial amygdalar nucleus) MBA:319 · Mouse

No perirhinal labelling was found in the basomedial subdomain.

Fig. 3j, k

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.