Schizophrenia-Related Microdeletion Impairs Emotional Memory through MicroRNA-Dependent Disruption of Thalamic Inputs to the Amygdala

MGm (Medial geniculate complex, medial part) MBA:1088 projects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

CAV2-Cre injected into the lateral amygdala was taken up by axon terminals and retrogradely labelled neuronal cell bodies in the MGm, revealed as mCherry-positive cells (with Cre-dependent AAV in thalamus) and as tdTomato-positive cells in Ai14 reporter mice.

Fig. 7A, 7B; Fig. S8

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

CTX (Cerebral cortex) MBA:688 functionally connects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Stimulating cortical fibers in the external capsule evoked excitatory postsynaptic currents in lateral amygdala principal neurons; input-output relations and paired-pulse ratios of this cortico-LA pathway were indistinguishable between wild-type and Df(16)1/+ mice.

Fig. 1F, 1G, 1I

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

MGm (Medial geniculate complex, medial part) MBA:1088 functionally connects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Electrical stimulation of thalamic fibers in the internal capsule evoked glutamatergic excitatory postsynaptic currents in principal neurons of the lateral amygdala in acute slices, with paired-pulse depression and stimulus-intensity-dependent amplitudes; these responses were reduced in 22q11DS model mice and the presynaptic release probability deficit was reversed by a Drd2 antagonist.

Fig. 1F–1J; Fig. 5; Fig. 6

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

MGm (Medial geniculate complex, medial part) MBA:1088 functionally connects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Chemogenetic silencing restricted to thalamo-LA projections (hM4Di expressed via CAV2-Cre from the LA plus Cre-dependent AAV in MGm, activated by CNO) lowered the amplitude of electrically evoked thalamo-LA EPSCs and altered paired-pulse ratio relative to controls, confirming a functional thalamic drive onto LA neurons.

Fig. 7F, 7G

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.