Organization of Afferents along the Anterior–posterior and Medial–lateral Axes of the Rat Orbitofrontal Cortex

MOs (Secondary motor area) UBERON:0016634 projects to Isocortex UBERON:0001950 · Rat

PLO injections yielded only weak M2 labelling, limited to a single coronal plane on both sides.

Results, Motor cortex

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MD (Mediodorsal nucleus of thalamus) UBERON:0002739 projects to Isocortex UBERON:0001950 · Rat

PVO injections gave only light labelling across the lateral, medial and central MD.

Results, Thalamus; Fig. 4; Fig. 6A

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MOp (Primary motor area) UBERON:0001384 projects to Isocortex UBERON:0001950 · Rat

ALO injections labelled cells weakly but widely in ipsilateral M1, with moderate labelling in contralateral M1.

Results, Motor cortex; Fig. 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PERI (Perirhinal area) UBERON:0006083 projects to Isocortex UBERON:0001950 · Rat

Perirhinal labelling after ALO injection was inconsistent across brains.

Results, Temporal lobe; Fig. S3

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

SSp-bfd (Primary somatosensory area, barrel field) UBERON:0010415 projects to Isocortex UBERON:0001950 · Rat

PLO injection left barrel cortex without labelled cells.

Results, Sensory cortex; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AI (Agranular insular area) UBERON:0034893 projects to Isocortex UBERON:0001950 · Rat

PVO injection produced weak to moderate labelled cell density in posterior agranular insular cortex.

Results, Intra-OFC projections

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

RE (Nucleus of reuniens) UBERON:0001921 projects to Isocortex UBERON:0001950 · Rat

PVO injections produced light labelling in nucleus reuniens.

Results, Thalamus; Fig. 2; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MOp (Primary motor area) UBERON:0001384 projects to Isocortex UBERON:0001950 · Rat

PVO injections labelled M1 in a pattern resembling ALO injections, though contralateral M1 labelling was weaker.

Results, Motor cortex; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ILA (Infralimbic area) UBERON:8440033 projects to Isocortex UBERON:0001950 · Rat

Posterior ventral OFC CTB injections produced weak but consistent infralimbic labelling.

Results, Medial prefrontal projections; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AUD (Auditory areas) UBERON:0001393 projects to Isocortex UBERON:0001950 · Rat

Primary auditory cortex had no labelled cells after PVO injection.

Results, Sensory cortex; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

SSp (Primary somatosensory area) UBERON:0008933 projects to Isocortex UBERON:0001950 · Rat

No labelled cells in S1 limb and trunk areas after PLO injection.

Results, Sensory cortex; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MOs (Secondary motor area) UBERON:0016634 projects to Isocortex UBERON:0001950 · Rat

PVO injections labelled M2 in a pattern resembling ALO injections.

Results, Motor cortex; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MOs (Secondary motor area) UBERON:0016634 projects to Isocortex UBERON:0001950 · Rat

ALO injections produced weak but widespread retrograde labelling in M2.

Results, Motor cortex; Fig. 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

LA (lateral amygdaloid nucleus) UBERON:0002886 projects to Isocortex UBERON:0001950 · Rat

PVO injection left the lateral amygdala without labelled cells.

Results, Amygdala; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PERI (Perirhinal area) UBERON:0006083 projects to Isocortex UBERON:0001950 · Rat

Perirhinal cortex contained labelled cells after PVO tracer injection.

Results, Temporal lobe

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PT (Parataenial nucleus) UBERON:0002992 projects to Isocortex UBERON:0001950 · Rat

PLO injections consistently produced moderate labelling in the paratenial nucleus.

Results, Thalamus; Fig. 4; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ENTl (Entorhinal area, lateral part) UBERON:0007225 projects to Isocortex UBERON:0001950 · Rat

PVO injection labelled lateral entorhinal cortex more strongly than the lateral OFC injections did.

Results, Temporal lobe

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

SMT (Submedial nucleus of the thalamus) UBERON:0003031 projects to Isocortex UBERON:0001950 · Rat

PVO injections labelled Sub mainly in its anterior half, dorsal part foremost, peaking at -2.30 mm; overall Sub input to PVO exceeded that to ALO.

Results, Thalamus; Fig. 5; Fig. 6B-C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLA (basal amygdaloid nucleus) UBERON:0002887 projects to Isocortex UBERON:0001950 · Rat

PLO injection moderately labelled anterior basolateral amygdala and weakly labelled its posterior part (BLP); amygdala input to PLO exceeded that to ALO or PVO.

Results, Amygdala; Fig. 7; Fig. S7; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

SSp-bfd (Primary somatosensory area, barrel field) UBERON:0010415 projects to Isocortex UBERON:0001950 · Rat

PVO injection yielded weak to moderate labelling in barrel cortex, graded moderate in the summary table.

Results, Sensory cortex; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

SSp (Primary somatosensory area) UBERON:0008933 projects to Isocortex UBERON:0001950 · Rat

PVO injections labelled cells in S1 forelimb, hindlimb and trunk areas, graded weak in the summary table.

Results, Sensory cortex; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MOp (Primary motor area) UBERON:0001384 projects to Isocortex UBERON:0001950 · Rat

After PLO injection, motor cortex labelling was confined to M2, with M1 unlabelled.

Results, Motor cortex

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ACA (Anterior cingulate area) UBERON:0009835 projects to Isocortex UBERON:0001950 · Rat

PVO injections frequently labelled cells weakly in anterior cingulate area 24b.

Results, Medial prefrontal projections; Fig. S5; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ACA (Anterior cingulate area) UBERON:0009835 projects to Isocortex UBERON:0001950 · Rat

No consistent retrograde labelling in anterior cingulate area 24b after PLO injection.

Results, Medial prefrontal projections; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PL (Prelimbic area) UBERON:8440032 projects to Isocortex UBERON:0001950 · Rat

CTB injected into posterior ventral OFC gave weak but consistent labelling in prelimbic cortex.

Results, Medial prefrontal projections; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

RE (Nucleus of reuniens) UBERON:0001921 projects to Isocortex UBERON:0001950 · Rat

Nucleus reuniens was mostly unlabelled after ALO injections.

Results, Thalamus; Fig. 2; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

LA (lateral amygdaloid nucleus) UBERON:0002886 projects to Isocortex UBERON:0001950 · Rat

PLO injection labelled cells in the dorsolateral part of the lateral amygdala, with weak labelling also in its ventromedial and ventrolateral parts.

Results, Amygdala; Fig. 7; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PT (Parataenial nucleus) UBERON:0002992 projects to Isocortex UBERON:0001950 · Rat

PVO injections left the paratenial nucleus with very light to no labelling, scored absent in the summary table.

Results, Thalamus; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLA (basal amygdaloid nucleus) UBERON:0002887 projects to Isocortex UBERON:0001950 · Rat

PVO injection weakly labelled anterior basolateral amygdala, while BLP was unlabelled.

Results, Amygdala; Fig. 7; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

VIS (Visual areas) UBERON:0000411 projects to Isocortex UBERON:0001950 · Rat

Visual cortex had no labelled cells after PLO injection.

Results, Sensory cortex; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

OLF (Olfactory areas) UBERON:0002894 projects to Isocortex UBERON:0001950 · Rat

PVO injections produced moderate piriform labelling, which became weak posterior to -1.88 mm from bregma.

Results, Sensory cortex; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

VIS (Visual areas) UBERON:0000411 projects to Isocortex UBERON:0001950 · Rat

PVO injections weakly labelled the lateral, mediolateral and mediomedial parts of V2.

Results, Sensory cortex; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

LA (lateral amygdaloid nucleus) UBERON:0002886 projects to Isocortex UBERON:0001950 · Rat

The text reports weak LaDL labelling after ALO injection, but the summary table scores the lateral amygdala as unlabelled for ALO.

Results, Amygdala; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PERI (Perirhinal area) UBERON:0006083 projects to Isocortex UBERON:0001950 · Rat

Perirhinal labelling after PLO injection was inconsistent across brains.

Results, Temporal lobe; Fig. S4

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

ILA (Infralimbic area) UBERON:8440033 projects to Isocortex UBERON:0001950 · Rat

After CTB injection into anterior lateral OFC, infralimbic cortex was mostly devoid of labelled cells.

Results, Medial prefrontal projections; Table 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

PL (Prelimbic area) UBERON:8440032 projects to Isocortex UBERON:0001950 · Rat

After CTB injection into anterior lateral OFC, prelimbic cortex was mostly free of retrogradely labelled cells on both sides.

Results, Medial prefrontal projections; Table 2; Fig. S3

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.