Acute stress activates basolateral amygdala neurons expressing corticotropin-releasing hormone receptor type 1 (CRHR1): Topographical distribution and projection-specific activation in male and female rats

BLN (basolateral amygdaloid nuclear complex) UBERON:0006107 projects to ACB (Nucleus accumbens) UBERON:0001882 · Rat

CTB-488 injected into the NAc retrogradely labelled neurons in the basolateral amygdala complex, with labelled projection neurons more numerous in the medial region (and more numerous in females than males); labelling was essentially confined to the hemisphere ipsilateral to the injection.

Fig. 2A, Fig. 4D-E; Methods (stereotaxic surgery)

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

BLN (basolateral amygdaloid nuclear complex) UBERON:0006107 projects to CEA (central amygdaloid nucleus) UBERON:0002883 · Rat

A subset of CTB-labelled BLA neurons projecting to the CeA also expressed the CRHR1 reporter, showing that CRHR1-expressing BLA cells send axons to the CeA; the share of CeA projectors expressing CRHR1 exceeded that of NAc projectors.

Fig. 5A-C

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

BLN (basolateral amygdaloid nuclear complex) UBERON:0006107 projects to CEA (central amygdaloid nucleus) UBERON:0002883 · Rat

CTB-488 injected into the CeA retrogradely labelled neurons in the basolateral amygdala complex, with significantly more labelled projection neurons in the lateral than the medial region of the sampled BLA; labelling was essentially ipsilateral to the injection.

Fig. 2A, Fig. 4A-B; Methods (stereotaxic surgery)

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

BLN (basolateral amygdaloid nuclear complex) UBERON:0006107 projects to ACB (Nucleus accumbens) UBERON:0001882 · Rat

Some BLA neurons retrogradely labelled from the NAc also carried the CRHR1 reporter, indicating CRHR1-expressing BLA cells project to the NAc; in females a larger proportion of CRHR1 cells were NAc projectors than CeA projectors.

Fig. 5A-C

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.