Interactive effects of early life adversity and adolescent basolateral amygdala activity on corticolimbic connectivity and behavior

BLN (basolateral amygdaloid nuclear complex) UBERON:0006107 functionally connects to PL (Prelimbic area) UBERON:8440032 · Rat

In anesthetized adolescent rats, single-pulse electrical stimulation of the BLA at increasing intensities evoked local field potentials in the prelimbic cortex, and these responses were larger in maternally separated animals of both sexes than in controls.

Fig. 1; Results, section 'MS leads to facilitation of BLA-evoked LFP'

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLN (basolateral amygdaloid nuclear complex) UBERON:0006107 projects to ILA (Infralimbic area) UBERON:8440033 · Rat

BLA-originating mCherry-labelled boutons were quantified in layers 2 and 5 of the infralimbic cortex, with more innervation in layer 2 in the right hemisphere and higher counts in maternally separated rats.

Fig. 3G-I; Results, section 'Chemogenetic BLA inhibition'

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

BLN (basolateral amygdaloid nuclear complex) UBERON:0006107 projects to PL (Prelimbic area) UBERON:8440032 · Rat

After AAV9-CaMKIIa-hM4Di-mCherry injection into the BLA, mCherry-labelled axonal boutons were detected and counted in layers 2 and 5 of the prelimbic cortex, with layer 2 receiving more boutons than layer 5; maternal separation increased bouton counts.

Fig. 3A-F; Results, section 'Chemogenetic BLA inhibition'

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.