Processing of visually evoked innate fear by a non-canonical thalamic pathway

LP (Lateral posterior nucleus of the thalamus) MBA:218 synapses onto LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Monosynaptic EnvA-rabies tracing from starter cells in the LA labelled presynaptic neurons in the LP, mostly in the LR and MC subdivisions. These neurons sat among SC-derived axon terminals.

Fig. 5b,c; Supplementary Fig. 9d

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SCm (Superior colliculus, motor related) MBA:294 functionally connects to LA (Lateral amygdalar nucleus) MBA:131 · Mouse

Pulsed 20-Hz light delivered to ChR2-expressing ILSCm CaMKIIa neurons activated a subset of ipsilateral LA units at short latency, both in anesthetized and in freely moving mice. Stimulating ILSCm axon terminals in the LP also evoked short-latency LA responses, consistent with a route relayed through the LP.

Fig. 3f-j; Fig. 4; Supplementary Fig. 7; Fig. 6j,k

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SCm (Superior colliculus, motor related) MBA:294 projects to PAG (Periaqueductal gray) MBA:795 · Mouse

After CaMKIIa-ChR2-mCherry expression in the ILSCm, only sparse mCherry-labelled axon fibres were seen in the adjacent PAG (and deep SC layers).

Supplementary Fig. 1a,b; Results, section 2

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SCm (Superior colliculus, motor related) MBA:294 projects to LP (Lateral posterior nucleus of the thalamus) MBA:218 · Mouse

AAV-CaMKIIa-EYFP injected into the ILSCm labelled axons that prominently innervated the LP. These axons overlapped with LP neurons that were retrogradely labelled from the LA.

Fig. 5a-c; Supplementary Fig. 9

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