Disrupted basolateral amygdala circuits supports negative valence bias in depressive states

LA (Lateral amygdalar nucleus) MBA:131 synapses onto BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

The percentage of rabies-labelled inputs to BLA-to-CeA neurons was quantified separately for the lateral amygdala and the BLA, showing that LA neurons provide inputs to this population.

Fig. 3I

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LA (Lateral amygdalar nucleus) MBA:131 projects to CEA (Central amygdalar nucleus) MBA:536 · Mouse

CTB injected into the CeA labelled lateral amygdala neurons, including cells double-labelled from the NAc injection.

Fig. S5; Table S3

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PVT (Paraventricular nucleus of the thalamus) MBA:149 synapses onto BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Projection-specific monosynaptic rabies tracing from BLA neurons projecting to NAc labelled input cells in anterior and posterior PVT. The PVT supplied about 67% of thalamic inputs, and about a third of these inputs were CaMKIIα-positive. Chronic CORT reduced anterior PVT inputs.

Results, presynaptic connectivity section; Fig. 3H

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PVT (Paraventricular nucleus of the thalamus) MBA:149 synapses onto BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Rabies tracing from BLA neurons projecting to CeA labelled PVT input neurons, which made up about 64% of thalamic inputs. Many were CaMKIIα-positive, and their number did not change with CORT.

Results, presynaptic connectivity section

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PAL (Pallidum) MBA:803 synapses onto BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Rabies-labelled input neurons to BLA-to-CeA cells were found in the pallidum, and their number was reduced after CORT.

Fig. 3G; Fig. S6I

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BLA (Basolateral amygdalar nucleus) MBA:295 projects to CEA (Central amygdalar nucleus) MBA:536 · Mouse

CTB555 injected into the central amygdala, aimed at its centromedial part, retrogradely labelled BLA neurons. Some BLA cells were double-labelled from both NAc and CeA injections.

Fig. 2A-C; Fig. S4D

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LA (Lateral amygdalar nucleus) MBA:131 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

CTB injected into the NAc also labelled lateral amygdala neurons. Activity of this LA-to-NAc population was analysed separately from basal BLA.

Fig. S5; Table S3

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

MO (Somatomotor areas) MBA:500 synapses onto BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Somatomotor areas contained rabies-labelled input neurons to BLA-to-NAc cells, and these were fewer in CORT-treated mice.

Fig. 3F; Fig. S6H

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BLA (Basolateral amygdalar nucleus) MBA:295 projects to ACB (Nucleus accumbens) MBA:56 · Mouse

CTB647 injected into the nucleus accumbens retrogradely labelled neurons in the basal BLA, defining a BLA-to-NAc population whose c-Fos recruitment was then quantified.

Fig. 2A-C; Fig. S4D

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.