The rostroventral part of the thalamic reticular nucleus modulates fear extinction

RT (Reticular nucleus of the thalamus) MBA:262 synapses onto DORpm (Thalamus, polymodal association cortex related) MBA:856 · Mouse

Monosynaptic rabies tracing starting from CeA-projecting dMTm neurons labelled presynaptic cells in the TRNrv, replicated in additional mice.

Fig. 6i–k; Supplementary Fig. 8

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

RT (Reticular nucleus of the thalamus) MBA:262 projects to DORpm (Thalamus, polymodal association cortex related) MBA:856 · Mouse

Cre-dependent GFP virus injected into the rostral TRN of PV-Cre mice labelled axons spread across both the medial and lateral parts of the dorsal midline thalamus.

Fig. 1a–d

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

RT (Reticular nucleus of the thalamus) MBA:262 functionally connects to DORpm (Thalamus, polymodal association cortex related) MBA:856 · Mouse

In vivo, 10 Hz ChR2 stimulation of TRNrv PV neurons suppressed spiking in most recorded dMTm units, leaving the rest unchanged and exciting none.

Fig. 4a

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RT (Reticular nucleus of the thalamus) MBA:262 projects to DORpm (Thalamus, polymodal association cortex related) MBA:856 · Mouse

CTB injected into the dMTl labelled neurons in the rostrodorsal TRN but not the rostroventral TRN, indicating segregated projections from the two TRN subdivisions.

Fig. 1e–m; Supplementary Fig. 1

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

DORpm (Thalamus, polymodal association cortex related) MBA:856 projects to CEA (Central amygdalar nucleus) MBA:536 · Mouse

Retrograde-Cre AAV injected into the CeA drove Cre-dependent helper expression in dMTm neurons, whose axon terminals were seen confined to the CeA.

Fig. 6a, c, f–h

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.