A crucial role for the cortical amygdala in shaping social encounters

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 projects to CEA (Central amygdalar nucleus) MBA:536 · Mouse

Synaptophysin-mRuby anterograde labelling from COApl Esr1 cells revealed presynaptic puncta in the central amygdala.

Extended Data Fig. 10b,d

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 synapses onto MEA (Medial amygdalar nucleus) MBA:403 · Mouse

Trans-synaptic HSV-1 tracing from the COApl revealed labelled downstream cells in the medial amygdala.

Fig. 5a

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 synapses onto PAA (Piriform-amygdalar area) MBA:788 · Mouse

Trans-synaptic HSV-1 tracing from the COApl labelled cells in the piriform-amygdalar area.

Fig. 5a

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 synapses onto CEA (Central amygdalar nucleus) MBA:536 · Mouse

Anterograde HSV-1 trans-synaptic tracing from the COApl labelled cells in the central amygdala.

Fig. 5a; Extended Data Fig. 10a

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) disagrees. “The cited Extended Data Fig. 10a reports no labelled CEA cells at 48 h, so that locator does not show the connection.”

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 synapses onto EP (Endopiriform nucleus) MBA:942 · Mouse

Trans-synaptic tracing from COApl Esr1 cells labelled the endopiriform nucleus.

Fig. 5a

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 functionally connects to CEA (Central amygdalar nucleus) MBA:536 · Mouse

ChR2-assisted mapping showed monosynaptic glutamatergic EPSCs, blocked by NBQX, in CEA neurons after stimulating COApl Esr1 terminals.

Extended Data Fig. 10d

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 synapses onto TR (Postpiriform transition area) MBA:566 · Mouse

Trans-synaptic HSV-1 tracing from the COApl labelled cells in the postpiriform transition area.

Fig. 5a

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 synapses onto SI (Substantia innominata) MBA:342 · Mouse

The substantia innominata is named among regions targeted by COApl Esr1 neurons in the paper's downstream tracing.

Results, 'Inhibiting COApl alters network connectivity'; Fig. 5a

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 synapses onto BST (Bed nuclei of the stria terminalis) MBA:351 · Mouse

Trans-synaptic HSV-1 tracing from the COApl labelled downstream cells in the bed nucleus of the stria terminalis.

Fig. 5a

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 synapses onto PVH (Paraventricular hypothalamic nucleus) MBA:38 · Mouse

The schematic of regions receiving trans-synaptic HSV-1 input from COApl Esr1 cells includes the paraventricular hypothalamic nucleus.

Fig. 5a

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) is unsure. “PVH appears only as a Fig. 5 abbreviation, and no text or caption states it was labelled.”

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 synapses onto AON (Anterior olfactory nucleus) MBA:159 · Mouse

Trans-synaptic HSV-1 tracing from the COApl labelled cells in the anterior olfactory nucleus.

Fig. 5a

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 synapses onto AVPV (Anteroventral periventricular nucleus) MBA:272 · Mouse

The red cluster is described as containing targets of COApl Esr1 neurons, including the anteroventral periventricular nucleus, based on the paper's downstream tracing.

Results, 'Inhibiting COApl alters network connectivity'; Fig. 5a

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 synapses onto ARH (Arcuate hypothalamic nucleus) MBA:223 · Mouse

The regions shown as receiving HSV-1 trans-synaptic input from COApl Esr1 cells include the arcuate hypothalamic nucleus.

Fig. 5a

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) is unsure. “ARH appears only in the Fig. 5 abbreviation list, with no stated labelling result.”

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 functionally connects to VMH (Ventromedial hypothalamic nucleus) MBA:693 · Mouse

Light activation of ChR2-expressing COApl Esr1 terminals evoked monosynaptic (TTX/4-AP resistant), NBQX-sensitive EPSCs in VMH neurons in slices.

Extended Data Fig. 10c

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 synapses onto ACB (Nucleus accumbens) MBA:56 · Mouse

The regions shown as receiving HSV-1 trans-synaptic input from COApl Esr1 cells include the nucleus accumbens.

Fig. 5a

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) is unsure. “NAc appears only in the Fig. 5 abbreviation list, and the text never reports it as labelled.”

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 synapses onto OT (Olfactory tubercle) MBA:754 · Mouse

The regions shown as receiving HSV-1 trans-synaptic input from COApl Esr1 cells include the olfactory tubercle.

Fig. 5a

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) is unsure. “OT appears only in the Fig. 5 abbreviation list, with no described labelling result.”

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 projects to VMH (Ventromedial hypothalamic nucleus) MBA:693 · Mouse

Cre-dependent synaptophysin-mRuby AAV injected into COApl of Esr1-Cre mice produced mRuby+ presynaptic puncta in the VMH.

Extended Data Fig. 10b,c

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 synapses onto PIR (Piriform area) MBA:961 · Mouse

HSV-1 anterograde trans-synaptic tracing from the COApl labelled cells in the piriform cortex.

Fig. 5a

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

COApl (Cortical amygdalar area, posterior part, lateral zone) MBA:655 synapses onto VMH (Ventromedial hypothalamic nucleus) MBA:693 · Mouse

HSV-1 H129 anterograde trans-synaptic tracing from the COApl in Esr1-Cre mice labelled downstream cells in the ventromedial hypothalamus.

Fig. 5a; Extended Data Fig. 10a

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) disagrees. “The cited Extended Data Fig. 10a shows no labelled VMH cells at 48 h, so that locator does not support labelling.”