Gradual wiring of olfactory input to amygdala feedback circuits

COApm (Cortical amygdalar area, posterior part, medial zone) MBA:663 projects to AOB (Accessory olfactory bulb) MBA:151 · Mouse

Cholera toxin B injected into the AOB granule layer retrogradely labelled corticobulbar projection neurons in layers II/III of the posteromedial cortical amygdala, which were then targeted for recording.

Fig. 2A; Fig. 8A; Methods (Stereotaxic injections)

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

AOB (Accessory olfactory bulb) MBA:151 functionally connects to COApm (Cortical amygdalar area, posterior part, medial zone) MBA:663 · Mouse

Electrical stimulation of PmCo layer Ia fibers, mostly AOB afferents, evoked fast EPSCs in Ct-b-labelled ACPs that were blocked by glutamate receptor antagonists; the proportion of responding ACPs increased with age, reaching 93% around postnatal days 40-50.

Fig. 2B, 2E; Fig. 6; Results, 'Postnatal increase in ACP responses to evoked AOB-MC input'

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AOBmi (Accessory olfactory bulb, mitral layer) MBA:204 functionally connects to COApm (Cortical amygdalar area, posterior part, medial zone) MBA:663 · Mouse

Light activation of ChR2-expressing mitral cell axons (Pcdh21-cre;ChR2) in PmCo layers I-III evoked glutamatergic EPSCs in Ct-b-labelled ACPs, blocked by DNQX and AP5; the fraction of responding ACPs rose with age, reaching all cells tested around postnatal days 25-30.

Fig. 2C-F; Results, 'Postnatal increase in ACP responses to evoked AOB-MC input'

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.